The Nano-Bio-Photonics Lab at the Institute of Atomic and Molecular Sciences (IAMS), Academia Sinica, Taiwan, is a dynamic, multidisciplinary research team dedicated to advancing optical microscopy techniques. Our mission is to unravel the fundamental dynamic phenomena in biological systems at the nanoscale. By integrating molecular biology and biochemistry with cutting-edge optical technology, we study the spatiotemporal dynamics of individual biological nano-objects—from molecules to viruses—to reveal how seemingly random events at this scale drive essential life processes. 

Our team pioneers new approaches in scattering-based optical interference microscopy and its application to sensitive and fast measurements of nanoscopic objects. Through interferometric detection, we capture the rapid dynamics of very small particles at ultrahigh speeds—up to 500,000 frames per second. We also design novel image processing and data analysis methods, leveraging statistical analysis and simulation to systematically investigate previously uncharted biological phenomena.