Nano-Bio-Photonics Lab is a multidisciplinary research team at the Institute of Atomic and Molecular Sciences (IAMS), Academia Sinica, Taiwan. We developed new optical microscope techniques and novel data analytical methods, aiming to elucidate the fundamental physics and chemistry events in living systems at the nanoscale. By combining molecular biological approaches and advanced optical technology, we experimentally measure the dynamics of individual biological nano-objects, from single viruses to single molecules, at high spatiotemporal resolutions. These small objects move constantly in biological systems due to thermal fluctuation, interacting with the surrounding environments. Our goal is to understand how life is constructed based on these stochastic events. These studies also shed new light on the origin of diseases, including viral infection and neurological disorders.

To perform the research aforementioned, we develop new techniques for optical observation, microscopic manipulation, nanoparticle labeling, and data analysis. For example, we have devoted ourselves to develop new imaging methods that utilize linear scattering of light as the signal. Through interferometric detection, we are able to capture extremely rapid dynamics of small particles/molecules under the microscope at ultrahigh speed (up to 500,000 frames per second). We also develop new methods of image processing and data analysis. Through statistical analysis and simulation, we aim to resolve live phenomena that have not been explored.