The Nano-Bio-Photonics Lab at the Institute of Atomic and Molecular Sciences (IAMS), Academia Sinica, Taiwan is a multidisciplinary research team focused on developing optical microscope techniques and data analytical methods to better understand the fundamental physics and chemistry of living systems at the nanoscale. By combining molecular biology and advanced optical technology, the lab measures the spatiotemporal dynamics of individual biological nano-objects, from single viruses to molecules, in order to understand how stochastic events drive life processes. This research also contributes to the understanding of disease origins, including viral infection and neurological disorders.

We develop new techniques for optical observation, microscopic manipulation, nanoparticle labeling, and data analysis. For example, we have devoted ourselves to develop new imaging methods that utilize linear scattering of light as the signal. Through interferometric detection, we are able to capture extremely rapid dynamics of small particles and molecules under the microscope at ultrahigh speed (up to 500,000 frames per second). The lab also develops new methods for image processing and data analysis, utilizing statistical analysis and simulation to explore previously unexplored phenomena.